Fig. 3: TG-affected genes are enriched for lipid metabolism and allergy pathways and show cell-specific expression patterns in line with gene function.
From: Lipid-induced transcriptomic changes in blood link to lipid metabolism and allergic response
a Pathway enrichments generated using a one-sided Fisher’s exact test with clusterProfiler56 using the 10 human pathway databases BioPlanet 2019, WikiPathways 2019 Human, KEGG 2019 Human, Elsevier Pathway Collection, BioCarta 2015, Reactome 2016, HumanCyc 2016, NCI-Nature 2016, Panther 2016, and MSigDB Hallmark 2020. The top 15 enrichments are shown. b Lipid metabolism genes are expressed in all blood cell types, but genes involved in allergy are expressed especially in basophils. Depicted are medians and interquartile range. Based on public RNA-seq data24 of T follicular helper (TFH), T regulatory cells (Treg), T helper 1 (Th1), T helper 1/T helper 17 (Th1.Th17), T helper 17 (Th17), T helper 2 (Th2), T CD4 terminal effector (CD4_TE), T CD4 Naive (CD4_naive), ϒ/δ Vd2+ (VD2.), ϒ/δ Vd2- (VD2..1), MAIT, T CD8 Naive (CD8_naive), T CD8 central memory (CD8_CM), T CD8 effector memory (CD8_EM), T CD8 terminal effector (CD8_TE), Progenitor cells, Naive B cells (B_naive), Non-switched memory (NSM) B cells (B_NSM), Exausted (Ex) B cells (B_Ex), Switched memory (SM) B cells (B_SM), Plasmablasts, Low-density (LD) neutrophils, NK cells (NK), Classical (C) monocytes (C_mono), Intermediate (I) monocytes (I_mono), Non-classical (NC) monocytes (NC_mono), Myeloid Dendritic Cells (mDC), Plasmacytoid Dendritic Cells (pDC), low-density (LD) basophils, and peripheral blood mononuclear cells (PBMC).
