Fig. 3: Chamber-specific molecular features of atrial CMs and fibroblasts. | Nature Communications

Fig. 3: Chamber-specific molecular features of atrial CMs and fibroblasts.

From: Single-cell transcriptomic analysis identifies murine heart molecular features at embryonic and neonatal stages

Fig. 3

A UMAP of A_CMs labeling the LA and RA-specific populations (LA1, RA1). B Stage analyses of LA1 and RA1 cells. C Expression heatmap of the top 20 genes differentially expressed in LA1 and RA1 cells. D mRNA staining confirmed the LA-specific expression of Ddit4l and RA-specific expression of Adm. E UMAP of fibroblasts revealed atrial and ventricular-specific cell populations (A1, V1). F The stage distribution of A1 and V1 cells. G Expression of the top 20 differentially expressed genes in A1 and V1 cells. H mRNA staining confirmed that Sfrp2 is specifically expressed in the atrium and Mest is specifically expressed in the ventricle. The staining experiments were repeated twice with similar results. Scale bar = 500 µm.

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