Fig. 9: Diagram illustrating the mechanism by which tumor-intrinsic YTHDF1 drives immune evasion. | Nature Communications

Fig. 9: Diagram illustrating the mechanism by which tumor-intrinsic YTHDF1 drives immune evasion.

From: Tumor-intrinsic YTHDF1 drives immune evasion and resistance to immune checkpoint inhibitors via promoting MHC-I degradation

Fig. 9

Briefly, YTHDF1 binds to a panel of lysosomal genes and facilitates its translation. On the contrary, YTHDF1 depletion limited lysosomal proteolysis in tumor cells, subsequently enhancing the MHC-I expression and minimizing the destruction of internalized antigens, which ultimately improve tumor immune surveillance and triggered a robust antitumor immunity.

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