Table 2 Predictive values, sensitivities and specificities for different study populations for APRI and GPR
Population, diagnostic targeta | Biomarker | Cut-off | PPV (%) | NPV (%) | Sensitivity (%) | Specificity (%) |
|---|---|---|---|---|---|---|
Asymptomatic screening, LSM > 12.2 kPa | APRI rule-in | 0.65 | 17.0 (13.9–20.2) | 98.4 (98.0–98.8) | 56.4 (45.9–66.9) | 90.6 (89.5–91.6) |
GPR rule-in | 0.47 | 20.1 (16.1–24.3) | 98.5 (98.1–99.0) | 69.7 (48.0–71.4) | 91.9 (90.5–93.3) | |
APRI Youden’s J | 0.54 | 14.0 (11.9–16.0) | 98.8 (98.4–99.2) | 68.8 (58.6–78.6) | 85.6 (84.3–86.8) | |
GPR Youden’s J | 0.37 | 13.9 (11.3–16.5) | 98.6 (98.1–99.0) | 63.4 (51.9–74.5) | 86.7 (85.0–88.4) | |
APRI rule-out | 0.36 | 7.4 (6.7–8.1) | 99.0 (98.7–99.4) | 80.7 (73.7–87.8) | 65.5 (64.0–67.1) | |
GPR rule-out | 0.23 | 7.8 (6.8–8.8) | 98.9 (98.5–99.4) | 79.4 (69.5–88.5) | 68.2 (66.1–70.3) | |
Suspected liver disease, LSM > 12.2 kPa | APRI rule-in | 0.65 | 70.5 (65.4–75.6) | 77.3 (74.6–79.9) | 56.6 (49.9–62.8) | 86.2 (83.2–89.1) |
GPR rule-in | 0.47 | 74.9 (48.9–93.7) | 73.0 (68.4–77.2) | 42.5 (32.0–52.5) | 90.6 (73.9–98.7) | |
APRI Youden’s J | 0.54 | 66.0 (61.5–70.3) | 79.4 (76.6–82.3) | 64.0 (58.0–70.0) | 80.7 (77.4–84.0) | |
GPR Youden’s J | 0.37 | 72.0 (51.7–87.8) | 76.8 (72.3–81.0) | 55.2 (44.2–64.9) | 86.3 (70.0–96.3) | |
APRI rule-out | 0.36 | 51.9 (49.0–54.7) | 83.2 (79.3–87.0) | 80.3 (75.1–85.4) | 56.7 (52.4–60.6) | |
GPR rule-out | 0.23 | 49.7 (40.8–63.7) | 81.2 (73.5–88.6) | 80.2 (73.4–86.6) | 51.3 (34.4–73.9) | |
Asymptomatic screening, LSM > 7.9 kPa | APRI rule-in | 0.65 | 10.7 (8.5–12.9) | 97.4 (97.3–97.6) | 28.8 (23.8–33.8) | 91.8 (90.7–92.9) |
GPR rule-in | 0.40 | 12.2 (9.8–14.6) | 97.7 (97.5–98.0) | 38.5 (32.1–44.8) | 90.5 (89.0–92.0) | |
APRI Youden’s J | 0.46 | 8.0 (7.0–9.0) | 97.9 (97.7–98.1) | 48.8 (43.7–53.9) | 80.9 (79.4–82.3) | |
GPR Youden’s J | 0.23 | 7.0 (6.3–7.7) | 98.3 (98.0–98.6) | 63.9 (58.1–69.7) | 71.0 (68.8–73.2) | |
APRI rule-out | 0.27 | 4.7 (4.4–5.0) | 98.5 (98.2–98.7) | 78.9 (75.0–82.9) | 45.4 (43.6–47.1) | |
GPR rule-out | 0.17 | 5.4 (5.0–5.8) | 98.5 (98.2–98.8) | 76.5 (71.4–81.1) | 54.1 (51.7–56.4) | |
Suspected liver disease, LSM > 7.9 kPa | APRI rule-in | 0.65 | 75.1 (68.8–80.7) | 74.9 (72.9–76.9) | 47.6 (42.3–53.2) | 90.8 (88.0–93.4) |
GPR rule-in | 0.40 | 83.6 (69.3–93.2) | 79.6 (74.3–83.5) | 59.0 (46.0–68.4) | 93.1 (85.5–97.6) | |
APRI Youden’s J | 0.46 | 66.9 (62.5–71.5) | 81.6 (79.2–84.1) | 69.0 (64.1–73.7) | 80.1 (76.2–83.8) | |
GPR Youden’s J | 0.23 | 60.2 (48.5–70.6) | 83.4 (78.6–88.1) | 76.2 (67.7–83.5) | 69.9 (53.6–82.8) | |
APRI rule-out | 0.27 | 44.7 (42.5–47.0) | 83.8 (79.4–88.4) | 87.9 (84.2–91.4) | 36.6 (31.8–41.8) | |
GPR rule-out | 0.17 | 51.8 (43.8–60.3) | 84.4 (78.1–89.8) | 82.8 (74.0–90.0) | 54.5 (38.4–69.9) |
