Fig. 3: Blockade of DNA sensors rescues the inflammatory profile upon altered mitochondrial dynamics. | Nature Communications

Fig. 3: Blockade of DNA sensors rescues the inflammatory profile upon altered mitochondrial dynamics.

From: Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation

Fig. 3

a Inflammatory profile in Mfn1KD myoblasts upon ODN2088 or Ru.521 treatment (1 µM, 24 h) (n = 4). b Inflammatory profile in Mfn2KD myoblasts upon ODN2088 or Ru.521 treatment (1 µM, 24 h) (n = 4). c Inflammatory profile in Fis1KD myoblasts upon ODN2088 or Ru.521 treatment (1 µM, 24 h) (n = 8). d Inflammatory profile in Drp1KD myoblasts upon ODN2088 or Ru.521 treatment (1 µM, 24 h) (n = 7). e Inflammatory profile upon Vdac1, Bax, Ppid, or DNaseIIa acute downregulation in Scr and Mfn1KD myoblasts (n = 4). a–e Two-way ANOVA test and post-hoc t tests. Data are expressed as mean of n independent experiments ± SEM.*p vs. Scr + vehicle <0.05 and #p vs. cognate KD + vehicle <0.05 in a–d; *p vs. Scr + siCtrl <0.05 and #p vs. cognate KD + siCtrl <0.05 in e. a–e Source data is provided in the Source Data File.

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