Fig. 1: Analysis of gene expression in peri-pubertal males and females.

a – Study design. We employed longitudinal and cross-sectional study designs to investigate the patterns of gene expression associated with pubertal development, b – Histograms of age distribution in females (left panel) and males (right panel) at baseline (tan) and at follow-up (green), c – Histograms of Pubertal Development Score31 distribution in females (left panel) and males (right panel) at baseline (tan) and at follow-up (green), d - Bar graph of menarcheal status in the cross-sectional sample.