Fig. 1: Optimization of the tagmentation rate and analysis of the tagmentation pattern.
From: TAPE-seq is a cell-based method for predicting genome-wide off-target effects of prime editor
a Tagmentation rates after 2 or 14 days; two-sided unpaired student t test. b Tagmentation and prime editing rates at nine different on-target sites. c Ratios of Case 1 and Case 2 editing determined by targeted deep sequencing and PE Analyzer. d Schematic of the TAPE-seq method. The bars represent the mean. Error bars indicate standard deviation (n = 3 independent transfections).
