Fig. 1: Single-cell transcriptomics profiling of the early endothelial-haematopoietic landscape. | Nature Communications

Fig. 1: Single-cell transcriptomics profiling of the early endothelial-haematopoietic landscape.

From: In vivo clonal tracking reveals evidence of haemangioblast and haematomesoblast contribution to yolk sac haematopoiesis

Fig. 1

a (i) Distribution of Flk1-GFP-expressing extraembryonic mesodermal derivatives at E7.75 (n = 7 embryos); (ii) Distribution of haematopoietic cells (GATA1+, white) and endothelium (GATA1− CDH5+, blue) at E8.5 (n = 12 embryos). Scale bars, 300 μm. b UMAP dimension reduction representation of 926 transcriptomes from cells collected from the yolk sac between E7.25–E10.5. c (i) Heatmap of key mesodermal, haematopoietic, endothelial, and mesenchymal genes expression in E7.25 to E10.5 yolk sac populations. (i) E7.25, (ii) E7.75, (iii) E8.5, (iv) E10.5. Endo: endothelium, EP endothelial precursors, Ery erythrocyte, EryP primitive erythrocyte, HEP haematoendothelial progenitors, haematopoietic progenitor/colony forming cells (HPC), Mac macrophage, Mk megakaryocyte, Mes mesenchyme, Meso derivatives mesodermal derivatives, Mes P mesenchymal precursors.

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