Fig. 4: Colocalizations between UL-GWAS signals and eQTL signals.
From: Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata
We estimated approximate Bayes factor colocalizations of UL association signals from META-2 and gene expression in GTEx v862 (cultured fibroblasts, skeletal muscle, uterus, and whole blood) using coloc.abf function from the coloc R library54. Altogether 92 genes, including the genes closest to the association lead variant at each UL-associated locus and biologically plausible candidate genes, when different from the closest genes, were included in the analysis (Table S2). The figure illustrates a all genes, the expression of which colocalizes with UL signal (posterior probability for a single causal variant [PP4] >0.8) in at least one of the studied tissues, as well as colocalization signals for HEATR3 in b cultured fibroblasts, c skeletal muscle, d uterus, and e whole blood, and for HSPA4 in f cultured fibroblasts, and g skeletal muscle.
