Table 1 Overview of 22 loci that have not been reported in association with UL in prior studies

From: Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata

Locus	Chr:Pos (hg38)	Nearest gene(s)	Candidate gene(s)	rsID	EA	EAF	OR (95% CI)	P value	HetPVal	INFO_FinnGen	FIN enr.
META-1
1q43	1:241860596	EXO1	EXO1, FH	rs4149909	G	0.03	1.13 (1.08-1.18)	1.16E-08	0.265	0.996	1.03
1q44	1:244151650	ZBTB18, C1orf100	ZBTB18, AKT3	rs2183478	G	0.18	1.07 (1.05-1.09)	1.75E-11	0.774	0.969	1.57
2q33.3	2:207258660	MYOSLID, KLF7	MYOSLID	rs10804157	C	0.44	1.04 (1.03-1.05)	1.04E-08	0.143	0.994	0.87
3q27.2	3:185807411	IGF2BP2	IGF2BP2	rs13060777	G	0.26	1.05 (1.04-1.07)	1.14E-11	0.595	0.999	1.10
4q23	4:99031559	METAP1	EIF4E, ADH5	rs1037475	G	0.57	1.04 (1.03-1.05)	8.38E-09	0.707	1.000	0.95
5q31.1	5:133099880	HSPA4	HSPA4	rs4367292	T	0.27	0.96 (0.94-0.97)	2.49E-08	0.882	0.997	1.15
6q21	6:109054915	SESN1	SESN1	rs11153158	C	0.13	0.93 (0.92–0.95)	1.05E-10	0.243	0.996	1.19
7p14.3	7:33008785	FKBP9, NT5C3A	NT5C3A, BBS9	rs4723230	T	0.80	1.05 (1.03-1.07)	4.68E-08	0.946	0.998	1.03
7q31.31	7:121132432	CPED1	WNT16	rs12706314	A	0.53	1.04 (1.03-1.06)	2.69E-10	0.777	0.998	0.89
7q32.3	7:130935964	LINC-PINT	LINC-PINT	rs35908158	C	0.08	1.08 (1.05-1.10)	1.60E-08	0.883	0.998	1.41
10p12.31	10:21517903	SKIDA1	DNAJC1	rs946711	C	0.33	1.05 (1.03-1.06)	2.96E-10	0.460	0.995	0.96
10q23.31	10:88331783	RNLS	RNLS	rs1426619	T	0.45	1.04 (1.03-1.06)	4.92E-09	0.653	0.998	1.09
11q23.2	11:112703765	ENSG00000285769	ENSG00000285769	rs10891420	C	0.42	1.05 (1.03-1.06)	1.38E-10	0.019	0.995	1.16
20q13.31	20:57441016	CTCFL	RBM38, BMP7	rs13039273	C	0.46	1.04 (1.03-1.06)	3.08E-09	0.874	0.995	1.22
21q22.12	21:35072824	RUNX1	RUNX1	rs2834747	G	0.30	0.96 (0.94-0.97)	1.44E-08	0.711	0.997	1.17
22q12.3	22:36287509	MYH9, APOL1	MYH9	rs9610482	T	0.19	1.06 (1.04-1.08)	7.89E-11	0.354	0.994	0.94
META-2
10q22.3	10:76884502	KCNMA1	KCNMA1	rs2082415	T	0.52^f	1.05 (1.03-1.06)	2.80E-08	0.460	0.949	1.11
10q24.32^a	10:101726828	FGF8	SLK	rs189195982	T	0.03^f	1.26 (1.17-1.36)	2.78E-10	0.285	0.994	198.19
10q24.32^a	10:102788270	WBP1L	SLK	rs75731980	T	0.06^f	1.23 (1.17-1.30)	2.42E-16	0.801	0.992	46.07
10q25.1^a	10:105587387	SORCS3	SLK	rs17119191	T	0.97^f	0.76 (0.70-0.82)	5.81E-13	0.314	0.977	49.89
10q25.1^a	10:106822067	SORCS1	SLK	rs1336619	T	0.03^f	1.25 (1.17-1.34)	3.48E-10	0.127	0.999	7.47
12q15	12:68692314	NUP107	MDM2	rs142808358	T	0.03^f	0.87 (0.83-0.91)	5.45E-09	0.958	0.987	0.87

‘Nearest gene(s)’ reports the gene closest to the association lead variant.
‘Candidate gene(s)’ indicates the biologically most relevant gene within a 1 Mb window around the association lead variant.
Chr chromosome, Pos position (build 38), EA effect allele, EAF effect allele frequency, OR odds ratio, CI confidence interval, P p value, HetPVal p value for heterogeneity, INFO_FinnGen imputation info in FinnGen, FIN enr Finnish enrichment (calculated as FIN AF/NFEE AF in the Genome Aggregation Database (gnomAD), where FIN AF is the Finnish allele frequency and NFEE AF is the non-Finnish-non-Estonian European allele frequency).
^aThe locus spans a genomic region larger than ±1 Mb.
^fFinnGen-based effect allele frequency (allele frequencies were not available for the genome-wide summary statistics of the previous study¹²).
The table reports distinct loci (more than 1 Mb apart) that contain at least one variant identified to be associated with UL at p < 5 × 10⁻⁸ and that have not been reported in association with UL in prior studies. META-1 is a meta-analysis of 53,534 UL cases and 373,024 female controls from FinnGen limited to the top 10,000 variants of a previously published meta-GWAS of UL¹², and META-2 is a meta-analysis of 38,466 UL cases and 329,473 female controls from FinnGen and the genome-wide results of the same meta-GWAS¹² excluding 23andMe data. All significant loci are listed in Tables S1, S2.

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Table 1 Overview of 22 loci that have not been reported in association with UL in prior studies

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