Fig. 3: Reaction conditions, scope and application of electricity-driven asymmetric bromocyclization of 2-amidostyrenes. | Nature Communications

Fig. 3: Reaction conditions, scope and application of electricity-driven asymmetric bromocyclization of 2-amidostyrenes.

From: Electricity-driven asymmetric bromocyclization enabled by chiral phosphate anion phase-transfer catalysis

Fig. 3

a Reaction scale: 3 (0.3 mmol), (R)-CPA2 (5 mol %), PTC2 (20 mol %), NaHCO3 (0.1 M in H2O), NaBr (1.0 M in H2O), toluene (6 mL), H2O (5 mL), Pt anode and cathode (10 mm × 10 mm × 0.2 mm), stirring speed: 1000 r/min, 4 mA (2.5–3.0 F mol−1), rt. Isolated yields were provided, and e.e. values were determined by chiral HPLC. +10 mol % of (R)-CPA2 was used. b Gram-scale protocol with 2 mol % of catalyst and high current for the synthesis of 4b and further transformations.

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