Table 1 Univariate and multivariate analysis of overall survival in 187 patients

		Univariate analysis		Multivariate analysis
Characteristics	No. of patients	HR (95% CI)	p value	HR (95% CI)	p value
Proteomic classifier		1.8 (1.4–2.2)	8.50E−07	1.5 (1.2–2)	0.00072
S-Ne	60
S-Pf	66
S-Pf	61
WHO classifier		1.3 (1.2–1.5)	2.90E−05	1.2 (1.1–1.4)	0.0083
WHO Grade2 Astrocytoma	9
WHO Grade2 Oligodendroglioma	18
WHO Grade3 Astrocytoma	2
WHO Grade4 Astrocytoma	6
GBM IDH1^mut	6
GBM IDH1^wt	138
Not elsewhere classified (NEC)	8
Age		0.57 (0.38–0.85)	0.0052	0.69 (0.46–1)	0.071
≥65 years	44
<65 years	143
Gender		1.3 (0.7–2.1)	0.068	1.1 (0.7–2.0)	0.063
Female	76
Male	111
Tumor site		1.1 (0.99−1.1)	0.088	1 (0.98−1.1)	0.19
Left frontal lobe	36
Left occipital lobe	10
Left parietal lobe	12
Left temporal lobe	18
Others	23
Right frontal lobe	37
Right occipital lobe	10
Right parietal lobe	21
Right temporal lobe	20

A univariant Cox PH model was used to evaluate the prognostic power of proteomic classifier, WHO classifier, age, gender and tumor sites on OS, respectively. The independence among proteomic classifier, WHO classifier, age, gender and tumor sites were estimated by a multivariate Cox PH model.

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