Fig. 3: Scope of alkenes for the coupling with aryl bromide 2.
From: Modulating stereoselectivity in allylic C(sp3)-H bond arylations via nickel and photoredox catalysis
Unless otherwise specified, the reactions were performed on a 0.2 mmol scale under the following reaction conditions: alkene (3 equiv.), aryl bromide (1 equiv.), 2,6-lutidine (1.5 equiv.), PC-1 (1 mol%), NiBr2 (10 mol%), dtbbpy (15 mol%), benzene/THF 1:1 (2 mL), rt, 48-72 h, yields and E/Z after purification by chromatography (numbers in parentheses refer to E/Z before purification). + tert-butyl acrylate (1 equiv.) was used as additive. TIPS, triisopropylsilyl. # Formal β-arylation of ketone was achieved after deprotection. *E/Z before isomerization, 49 (37:63), 50 (33:67), see Supporting Information for reaction condition details.
