Fig. 7: HMG20A is enriched at open chromatin regions and affects chromatin accessibility in mESCs. | Nature Communications

Fig. 7: HMG20A is enriched at open chromatin regions and affects chromatin accessibility in mESCs.

From: The H2A.Z and NuRD associated protein HMG20A controls early head and heart developmental transcription programs

Fig. 7

A Genome browser snapshots of representative HMG20A binding regions, as identified by CUT&RUN-seq of primed stage WT (blue) or Hmg20a DP clone #26 (light gray, negative control) mESCs. IgG antibody was used as negative control (black). Shown are two independent replicates (rep). B Venn diagram depicting overlay of CUT&RUN identified HMG20A binding sites with ATAC-seq identified accessible chromatin regions. C Density heatmap of ATAC-seq sites (two replicates) that become more open (cluster 1), remain unaffected (cluster 2) or become more closed (cluster 3) upon Hmg20a depletion. D Cumulative density plot showing the distribution of the observed changes in chromatin accessibility (shown as log2FC (DP/ET)) for all ATAC-seq signals (black) and for those ATAC-seq signals overlapping with HMG20A (red). DARs: differentially accessibly regions.

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