Fig. 9: Model of HMG20A’s function in chromatin and transcriptional regulation during development. | Nature Communications

Fig. 9: Model of HMG20A’s function in chromatin and transcriptional regulation during development.

From: The H2A.Z and NuRD associated protein HMG20A controls early head and heart developmental transcription programs

Fig. 9

Top: HMG20A associates with H2A.Z- and PWWP2A-associated PRTH and M1HR complexes and ZNF512B as well as BHC/CoREST and NuRD complexes and TEAD and L3MBTL3 that are not part of H2A.Z or PWWP2A interactomes. Middle: HMG20A binds to two distinct chromatin regulatory elements: (1) Nucleosome depleted regions (NDR) at promoter sites that are surrounded by H2A.Z-containing nucleosomes and bound by PWWP2A and that are associated with genes involved in basic processes, such as ‘chromatin organization‘. (2) H2A.Z-lacking intronic enhancers within transcribed genes belonging to developmental processes, such as ‘embryonic morphology”. Bottom: Depletion of HMG20A in Xenopus laevis and mESCs leads to changes in chromatin accessibility, deregulation of transcription programs as well as migration defects. HMG20A depleted cells fail to properly differentiate into neural crest cells or cardiomyocytes in mESCs as well as head and heart in Xenopus laevis. Figure was created with BioRender.

Back to article page