Table 1 Association of genetic variants with narcolepsy. Raw P-values are reported using two-sided fixed-effects meta-analysis

From: Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

       

Meta-analysis of transethnic cohorts,

Meta-analysis of vaccination cases

Meta-analysis of vaccination and non-vaccination cohorts

No vaccination cases

Closest gene

chr

rsid

Position

Other

Effect

Allele

P-value

beta

SE

P-value

beta

se

P-value

beta

se

n cases

n controls

Allele

Allele

Frequency

Vaccination

TNFSF4

1

rs10158467

173131493

A

G

0.29

6.64 × 10−8

0.159

0.029

0.108

0.175

0.109

1.77 × 10−08

0.16

0.028

5601

86,675

DENND1B

1

rs12131588

197666111

G

A

0.19

3.52 × 10−9

0.17

0.029

0.191

0.164

0.126

1.46 × 10−09

0.17

0.028

5601

86,675

CD207

2

rs3815556

71059153

A

G

0.062

3.33 × 10−10

0.246

0.039

0.05

0.432

0.22

6.62 × 10−11

0.251

0.039

6073

87,377

NAB1

2

rs72917118

191486081

C

T

0.192

1.03 × 10−09

−0.205

0.034

0.039

−0.288

0.139

1.38 × 10−10

−0.209

0.033

5601

86,675

TRB

7

rs7458379

142038166

C

T

0.394

8.03 × 10−12

0.155

0.023

0.019

0.306

0.13

9.40 × 10−13

0.16

0.022

5998

84,581

ZNF365

10

rs10995245

64391375

G

A

0.348

4.15 × 10−12

0.148

0.021

0.302

0.106

0.103

2.62 × 10−12

0.147

0.021

6073

87,377

CTSC

11

rs7112455

88051293

T

A

0.052

5.58 × 10−09

0.244

0.042

0.06

0.373

0.199

1.12 × 10−09

0.249

0.041

6073

87,377

IKZF4-ERBB3

12

rs11171731

56443342

C

T

0.33

5.72 × 10−09

0.147

0.025

0.019

0.239

0.101

4.97 × 10−10

0.152

0.024

5601

86,675

TRA

14

rs1154155

23002684

T

G

0.17

2.28 × 10−76

0.463

0.025

1.65 × 10−13

0.85

0.115

7.31 × 10−86

0.48

0.024

6073

87,377

CTSH

15

rs34593439

79234957

G

A

0.11

2.56 × 10−09

0.215

0.036

0.003

0.437

0.147

8.24 × 10−11

0.227

0.035

6073

87,377

SIRPG

20

rs6034239

1616137

G

A

0.575

1.21 × 10−08

0.123

0.022

0.056

0.215

0.113

2.61 × 10−09

0.126

0.021

5992

86,957

IFNAR1

21

rs2096464

34686049

G

T

0.301

4.55 × 10−14

−0.179

0.024

0.653

−0.052

0.115

7.40 × 10−14

−0.174

0.023

6073

87,377

Novel loci in Z-score-based analysis

        

PRF1

10

rs78325861

72378489

C

G

0.046

2.27 × 10−06

−0.338

0.072

0.717

−0.156

0.432

3.4 × 10−09

−0.333

0.071

5605

85,481

  1. Allele frequencies are given for effect allele, position reflects hg19.