Table 1 Association of genetic variants with narcolepsy. Raw P-values are reported using two-sided fixed-effects meta-analysis
From: Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy
Meta-analysis of transethnic cohorts, | Meta-analysis of vaccination cases | Meta-analysis of vaccination and non-vaccination cohorts | |||||||||||||||
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No vaccination cases | |||||||||||||||||
Closest gene | chr | rsid | Position | Other | Effect | Allele | P-value | beta | SE | P-value | beta | se | P-value | beta | se | n cases | n controls |
Allele | Allele | Frequency | Vaccination | ||||||||||||||
TNFSF4 | 1 | rs10158467 | 173131493 | A | G | 0.29 | 6.64 × 10−8 | 0.159 | 0.029 | 0.108 | 0.175 | 0.109 | 1.77 × 10−08 | 0.16 | 0.028 | 5601 | 86,675 |
DENND1B | 1 | rs12131588 | 197666111 | G | A | 0.19 | 3.52 × 10−9 | 0.17 | 0.029 | 0.191 | 0.164 | 0.126 | 1.46 × 10−09 | 0.17 | 0.028 | 5601 | 86,675 |
CD207 | 2 | rs3815556 | 71059153 | A | G | 0.062 | 3.33 × 10−10 | 0.246 | 0.039 | 0.05 | 0.432 | 0.22 | 6.62 × 10−11 | 0.251 | 0.039 | 6073 | 87,377 |
NAB1 | 2 | rs72917118 | 191486081 | C | T | 0.192 | 1.03 × 10−09 | −0.205 | 0.034 | 0.039 | −0.288 | 0.139 | 1.38 × 10−10 | −0.209 | 0.033 | 5601 | 86,675 |
TRB | 7 | rs7458379 | 142038166 | C | T | 0.394 | 8.03 × 10−12 | 0.155 | 0.023 | 0.019 | 0.306 | 0.13 | 9.40 × 10−13 | 0.16 | 0.022 | 5998 | 84,581 |
ZNF365 | 10 | rs10995245 | 64391375 | G | A | 0.348 | 4.15 × 10−12 | 0.148 | 0.021 | 0.302 | 0.106 | 0.103 | 2.62 × 10−12 | 0.147 | 0.021 | 6073 | 87,377 |
CTSC | 11 | rs7112455 | 88051293 | T | A | 0.052 | 5.58 × 10−09 | 0.244 | 0.042 | 0.06 | 0.373 | 0.199 | 1.12 × 10−09 | 0.249 | 0.041 | 6073 | 87,377 |
IKZF4-ERBB3 | 12 | rs11171731 | 56443342 | C | T | 0.33 | 5.72 × 10−09 | 0.147 | 0.025 | 0.019 | 0.239 | 0.101 | 4.97 × 10−10 | 0.152 | 0.024 | 5601 | 86,675 |
TRA | 14 | rs1154155 | 23002684 | T | G | 0.17 | 2.28 × 10−76 | 0.463 | 0.025 | 1.65 × 10−13 | 0.85 | 0.115 | 7.31 × 10−86 | 0.48 | 0.024 | 6073 | 87,377 |
CTSH | 15 | rs34593439 | 79234957 | G | A | 0.11 | 2.56 × 10−09 | 0.215 | 0.036 | 0.003 | 0.437 | 0.147 | 8.24 × 10−11 | 0.227 | 0.035 | 6073 | 87,377 |
SIRPG | 20 | rs6034239 | 1616137 | G | A | 0.575 | 1.21 × 10−08 | 0.123 | 0.022 | 0.056 | 0.215 | 0.113 | 2.61 × 10−09 | 0.126 | 0.021 | 5992 | 86,957 |
IFNAR1 | 21 | rs2096464 | 34686049 | G | T | 0.301 | 4.55 × 10−14 | −0.179 | 0.024 | 0.653 | −0.052 | 0.115 | 7.40 × 10−14 | −0.174 | 0.023 | 6073 | 87,377 |
Novel loci in Z-score-based analysis | |||||||||||||||||
PRF1 | 10 | rs78325861 | 72378489 | C | G | 0.046 | 2.27 × 10−06 | −0.338 | 0.072 | 0.717 | −0.156 | 0.432 | 3.4 × 10−09 | −0.333 | 0.071 | 5605 | 85,481 |