Fig. 2: Fmo-2 interacts with OCM genes to regulate lifespan. | Nature Communications

Fig. 2: Fmo-2 interacts with OCM genes to regulate lifespan.

From: FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans

Fig. 2

a Diagram of OCM network. Genes included here are labeled in blue and genes not included are labeled in gray. Lifespan analysis comparing the wild type, FMO-2 OE and FMO-2 KO on empty-vector (EV) and b alh-3 RNAi, c atic-1 RNAi, d sams-1 RNAi, e mel-32 RNAi, f cth-2 RNAi, g mtrr-1 RNAi, and h Y106G6E.4 RNAi. Percent change in mean lifespan compared to their respective EV controls are shown in the left bottom corner of the figures. Black circle = wild type, blue diamond = FMO-2 OE, and red triangle= FMO-2 KO. Solid line = EV and dotted line = RNAi. * denotes significant change in mean lifespan at p < 0.05 using log-rank and # denotes significant interaction between the RNAi of interest and fmo-2 genotype at p < 0.01 using Cox regression analysis. N.S. = not significant. Statistics are in Table 1, Supplementary Table 5, and Supplementary Data 5.

Back to article page