Fig. 6: Proposed model. | Nature Communications

Fig. 6: Proposed model.

From: FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans

Fig. 6

In control conditions, there is very low fmo-2 expression, leading to low levels of tryptophan metabolism/kynurenine production through FMO-2, and maintaining normal flux through one carbon metabolism and normal lifespan. When fmo-2 is induced, FMO-2 oxygenates tryptophan, leading to increased kynurenine production and decreased methylation output flux through OCM, thereby extending nematode lifespan. When fmo-2 is absent, these metabolic changes do not occur, preventing an extension in lifespan. The gray line represents decreased flux and the blue line represents increased flux.

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