Fig. 1: Sequence comparison of complete rustrela virus (RusV) genome sequences from cats from Sweden, Austria, and Germany. | Nature Communications

Fig. 1: Sequence comparison of complete rustrela virus (RusV) genome sequences from cats from Sweden, Austria, and Germany.

From: Mystery of fatal ‘staggering disease’ unravelled: novel rustrela virus causes severe meningoencephalomyelitis in domestic cats

Fig. 1

a The amino acid sequences of the structural polyprotein (p110/sPP) of all known matonaviruses were aligned and a maximum-likelihood (ML) phylogenetic tree was calculated (IQ-TREE2 version 2.2.0; FLU + F + I + G4; 100,000 ultrafast bootstraps). Bootstrap support values are shown in italics. b ML tree of complete or nearly complete RusV genome sequences from cats with ‘staggering disease’ and all publicly available RusV sequences (IQ-TREE2 version 2.2.0; TIM3 + F + I; 100,000 ultrafast bootstraps). Sequences from Sweden, Austria, and Germany are highlighted in blue, green, and orange, respectively. Sequences from a previously identified German RusV cluster from zoo animals with encephalitis and apparently healthy yellow-necked field mice (Apodemus flavicollis)37,38,40 are presented in a dashed box. Bootstrap support values are shown at the nodes. c The genetic variability of RusV lineages from Sweden, Austria, and Germany is presented as mean pairwise JC69 distance using a sliding window analysis (window: 200 nt; step size: 50 nt). The genomic organization of RusV is shown, highlighting the non-structural (p200/nsPP) and structural (p110/sPP) polyprotein open reading frames, as well as the mature cleavage products protease (p150), RNA-directed RNA polymerase (p90), capsid protein (C), and glycoproteins E2 and E1.

Back to article page