Fig. 4: Encephalitic pattern in rustrela virus (RusV)-infected cats. | Nature Communications

Fig. 4: Encephalitic pattern in rustrela virus (RusV)-infected cats.

From: Mystery of fatal ‘staggering disease’ unravelled: novel rustrela virus causes severe meningoencephalomyelitis in domestic cats

Fig. 4

Histology typically features polio-predominant, perivascular lymphohistiocytic cuffs (a–c: solid boxes) and angiocentric infiltrates (a–c: dashed boxes). They are most prominent in brain stem (a: Po), hippocampus formation (b) and neocortex (c). Leptomeningeal infiltrates (a: white arrowhead) also occur in areas with sparse parenchymal infiltration such as the cerebellum (a: Cer). Stain: haematoxylin eosin (H.E.). Anatomical landmarks: Cer: cerebellum; CWM: cerebellar white matter; GLC: granule cell layer of cerebellar cortex; GLD: granule cell layer of dentate gyrus; NCR: neocortical ribbon; PL: pyramidal cell layer; Po: pons; VIV: fourth ventricle; VL: lateral ventricle. Cats: a SWE_04; b, c SWE_07. Representative images of RusV-infected cats are presented. All case and control cats (n = 29 each) were analysed. Histopathological diagnoses are provided in Supplementary Tables 3 and 4.

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