Fig. 2: CSPs induced by different CAM-A and CAM-E compounds.

a Negative-staining EM micrographs corresponding to the ¹³C-¹⁵N Cp149 reassembled capsids in absence (for reference) or presence of CAM, with their chemical structure. The EM pictures were taken on single labeled samples, and experiments were repeated independently at least once on unlabeled samples and yielded similar results. b Extracts from the NMR DARR spectra showing the A11 and A137 alanine Cα-Cβ region for all tested compounds. In light gray is the control spectrum for comparison (from ref. ⁵³). For full aliphatic regions of DARR spectra, see Supplementary Fig. 4a. c CSPs induced by the different CAMs mapped on Cp149-HAP18 structure (PDB 5d7y³⁷) where unaffected residues are shown in gray, and residues affected by the binding are colored orange (medium CSPs, in sticks) and red (strong CSPs, in spheres). HAP18 is represented as blue spheres. For CSP graphs for all residues see Supplementary Fig. 5 and values in the Source Data file.