Fig. 3: PRC2 loss alters gene expression with and without changes in chromatin accessibility.
From: Epigenetic control of cellular crosstalk defines gastrointestinal organ fate and function
a, b DEGs between control and PRC2-Knockout (KO) Stomach (St) (a) and Intestine (Int) (b). c Comparison of Int and St DEGs in control (x-axis) and PRC2-knockout (y-axis) tissues. Only DEGs identified in control Int versus St and genes whose differential expression was significantly altered in PRC2-knockout Int versus St are shown and categorized by color as described in the panel. Top six genes per category are labeled. Dashed red line shows diagonal. d Correlation of promoter ATAC-seq signal and gene expression between PRC2-KO and control tissues. e Example tracks (Barx1 and Hoxa11) showing lineage-specific genes which alter chromatin accessibility (blue) and transcription (orange). f Example tracks (Wnt2 and Wnt11) demonstrating genes which alter transcription independent of chromatin accessibility upon PRC2 loss.
