Fig. 2: Substrate scope towards divergent Heck reactions.
From: Nickel-catalyzed divergent Mizoroki–Heck reaction of 1,3-dienes
a Substrate scopes of dienes for linear products. b Substrate scopes of Ar-I for linear products. c Substrate scopes of dienes for branched products. d Substrate scopes of Ar-OTf for branched products. e Cascade Heck reactions. Isolated yields were given in all cases. Selectivities were >20:1 except for some cases with footnotes, which were determined by GC-FID or 1H NMR analysis. aiodobenzene (9.0 mmol), 4a (6.0 mmol); b3a (0.20 mmol), 1,3-diene (0.60 mmol); cIsolated yield of two steps (coversion of -CO2H to -CO2Me); d1 (0.20 mmol), 4 (0.25 mmol), 4-CNC6H4Bneop (B2, 20 mol%) was used instead of B1; eA mixture of Z- and E-isomers of diene 4 was used; f1 (0.25 mmol); g1 (0.20 mmol), 4 (0.25 mmol), KOtBu was used instead of NaF; h1 (0.10 mmol), 4 (0.25 mmol), Ni(cod)2 (20 mol%), IPr∙HCl (24 mol%), Cs2CO3 (3.0 equiv.), B1 (40 mol%), KOtBu (40 mol%); i3a (1.0 mmol), 1,3-butadiene (3.0 mmol), MeCN/NEt3 (5.0 mL/0.60 mL = 9:1); jAr-I (0.60 mmol), 5n (0.40 mmol), MeCN/NEt3 (1.0 mL/0.11 mL = 9:1).
