Fig. 6: Perturbation of translation elongation induced by RocA in lung cancer and melanoma cells. | Nature Communications

Fig. 6: Perturbation of translation elongation induced by RocA in lung cancer and melanoma cells.

From: Reanalysis of ribosome profiling datasets reveals a function of rocaglamide A in perturbing the dynamics of translation elongation via eIF4A

Fig. 6

a Metagene plots of ERGs and IRGs with ribosome profiling data from different cancer cell lines. Melanoma: A375 cells and Hs936 cells; lung cancer: NCI-H1650 cells and NCI-H520 cells. b Enrichment ratio of ribosome density around poly-purine motifs (4mer) by comparisons between RocA and DMSO in A375, Hs936T, NCI-H520 and NCI-H1650 cells. P-values are all calculated by two-sided Student’s t test without adjustments. Source data are provided as a Source Data file.

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