Fig. 5: The association of DBP and 25OHD. | Nature Communications

Fig. 5: The association of DBP and 25OHD.

From: Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots

Fig. 5

Panels (a, b) show the GSMR results of DBP concentration, a the effect of DBP on 25OHD (SNPs n = 40); and b the effect of 25OHD on DBP (SNPs n = 201). The GSMR estimates are shown in each panel. The plots show the GSMR estimate of effect, and SE and P value, all of which were calculated by GSMR. P value was estimated from a two-tailed test. The dashed line represents the GSMR estimate of effect. The summary statistics of DBP is from this study, conducted in iPSYCH2012. The summary statistics of 25OHD is from the study of Revez et al., conducted in UKB. Panels (c, d) are the GSMR results of DBP concentration adjusted for GC genotypes, c the effect of DBP adjusted for GC on 25OHD (SNPs n = 10) and d the effect of 25OHD on DBP adjusted for GC (SNPs n = 222). The GWAS of adjusted DBP was conducted by fitting the GC diplotypes as covariates. The summary statistics of 25OHD are the same as above, from the study of Revez et al. All the GSMR analyses were conducted with HEIDI-outlier. The SNPs which were identified as pleiotropy were excluded. The bar shown in the graph represents the GWAS SE at each SNP with its center being the GWAS effect of SNP. The Bonferroni-corrected threshold was 0.025 (=0.05/2).

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