Fig. 1: Binding affinity between Fat4 and Dchs1 truncations.
From: Structure of the planar cell polarity cadherins Fat4 and Dachsous1
a Simplified cartoon comparing tissue organization by classical cadherins and Fat–Dachsous cadherins. Classical cadherins form homophilic interactions between cells to segregate tissues. Fat and Dachsous are expressed in the same cell and form heterophilic interactions to regulate planar cell polarity. b Schematic depicting the Fat4 and Dchs1 ECDs. The interacting EC1-4 domains are enlarged and the putative Fjx1 phosphorylation site is indicated in EC3 of each protein. c Representative ITC thermograms measuring the binding between Fat4 and Dchs1 constructs. KD measurements are an average of n = 2 independent experiments. Source data are provided as a Source Data file.
