Fig. 7: EMT diversity in single-cell data.

a Comparison between EMT pseudotime estimates in matched bulk and single-cell samples from the same individuals (Pearson correlation coefficient R and p-value are shown). b Number of interactions established between tumour cells found in an EPI, hEMT, or MES state and other cells in the tumour microenvironment in the Chung et al.⁵⁷ dataset. c Uniform Manifold Approximation and Projection (UMAP) reconstruction of single-cell expression profiles depicting the tumour and microenvironment landscape of breast, lung, colorectal and ovarian tumours from Qian et al.⁵⁸. Tumour cells are coloured according to their assigned EMT state (EPI/hEMT/MES). All other cells in the microenvironment are also depicted in different colours. DC dendritic cells, EC endothelial cells. d Heat maps depicting the total number of interactions established among all cell types in the same breast, lung, colorectal and ovarian datasets. The tumour cells are denoted by their EPI, hEMT and MES states. Source data are provided as a Source Data file.