Fig. 6: Analysis of gene expression responses in combined stress.

a Averaged log2fc of genes in Sx (type of stress indicated at the bottom), Sy (other stresses), and Sxy (combined stress). Blue, red, and gray circles indicate genes that are significantly downregulated, upregulated, and not changed, respectively. b Scatter plot depicting the outcome in combined stress, where red, blue, and gray dots indicate that the response is higher, lower, or within the range of the single stresses, respectively. c Break down of the response observed in combined stress Sxy. The heatmap reflects the proportion of events in a given stress (column), and the colors are normalized across each category of Sx and Sy. The actual number of observations is annotated in the cells. Blue, red, and gray circles indicate genes that are significantly downregulated, upregulated, and not changed, respectively. d Linear regression of the average log2fc values from panel (a). The inferred formula is shown, together with mean absolute error (MAE), root mean squared error (RMSE), and R2 (goodness-of-fit measure).