Fig. 3: eQTL signals associated with multiple genes.
From: Fine mapping spatiotemporal mechanisms of genetic variants underlying cardiac traits and disease
a Enrichment of eGenes that share the same eQTL signal with other eGenes or eIsoforms for having stage-, organ-, tissue- and cell type- eQTLs measured by linear regression analysis (n = 2778). Dots represent effect size and segments represent standard errors. Effect sizes, standard errors and p-values were measured using the lm function in R. b eGenes that share the same eQTL signals are enriched for being associated with same stage, organ, tissue, or cell type calculated using a permutation test. Dots represent Z-scores. c–h eQTL signals shared between a gene and its associated antisense RNA: c–e PAX8 and PAX8-AS1; f–h IRF1 and IRF1-AS1. c, f scatterplots showing the –log10 (eQTL p-value) for the gene (X axis; c: PAX8; f: IRF1) and for the antisense RNA (Y axis; c: PAX8-AS1; f: IRF1-AS1). d, e, g, h eQTL signal for the gene (in blue, panels d and g) and for the antisense RNA (in green, panels e and h).
