Fig. 6: Fine mapping of stage and cell type- eQTLs colocalizing with cardiac traits.
From: Fine mapping spatiotemporal mechanisms of genetic variants underlying cardiac traits and disease
a–e Pie charts showing for each cardiac trait the distribution of SNPs in 99% credible sets. The colors indicate the number of SNPs and the numbers around the perimeter indicate the number of credible sets. f Pie chart showing the overlap between the lead SNP at each GWAS signal in the five cardiac traits and the index SNP for the GWAS signal in the GWAS catalog for the same trait. SNPs in high LD have R2 > 0.8 and SNPs in low LD have 0.2 ≤ R2 ≤ 0.8. g–o Plots showing −log10(p-value) eQTL signals (top row; panels g, j, m, p), the GWAS signals (middle row; panels h, k, n, q) and the PPA of each variant in the colocalization (bottom row; panels i, l, o, r) at four loci: (g–i) CEP68 expression and atrial fibrillation; j–l PRKG1 (isoform ENST00000643582.1_1) expression and pulse pressure; m–o FLCN expression and pulse rate; and p–r ACTN2 expression and pulse rate.
