Fig. 3: NREM/IS slow vasomotion increases predicted PVS fluid velocity. | Nature Communications

Fig. 3: NREM/IS slow vasomotion increases predicted PVS fluid velocity.

From: Sleep cycle-dependent vascular dynamics in male mice and the predicted effects on perivascular cerebrospinal fluid flow and solute transport

Fig. 3

a Illustration showing the model of the PVS (top), and representative vasomotion-driven CSF flow simulation (bottom). b–d Peak fluid velocity in penetrating arteriole PVS generated by VLF and LF oscillations during a sleep cycle as predicted by biomechanical modeling using three scenarios where we added a fixed volume to the PVS obstructing flow corresponding to 0, 25, and 50% of our measured PVS in quiet wakefulness. The black circle represents the median, whereas the shading represents the distribution of all modeled vessels (n = 16 vessels, 4 mice). The value of the median is also given in the lower right corner for each box. WBS wake before sleep; NREM non-rapid eye movement sleep; IS intermediate state sleep; REM rapid eye movement sleep; WAS wake after sleep; PVS perivascular space; VLF very low frequency; LF low frequency. Source data are provided as a Source Data file.

Back to article page