Fig. 8: Schematic representation of central findings.
From: Antigen footprint governs activation of the B cell receptor
Left: Polyvalent antigen induces robust activation at both low and high stoichiometry, whereas monovalent antigen is only active at high stoichiometry, and small-molecule or small footprint monovalent antigen has no activity whatsoever. Right: The role of footprint in determining monovalent antigen activity. There is not a simple linear relationship between overall size and capacity for activation, rather, a combination of size and rigidity determines the degree of activation.
