Fig. 2: Gonadal loss in females mimics metabolic syndrome but does not trigger hepatic steatosis.
From: Intra-pituitary follicle-stimulating hormone signaling regulates hepatic lipid metabolism in mice
a, d Body weight, glucose tolerance (b, e), insulin tolerance (c, f), and liver oil red O staining quantification (g) and representative images (h scale bars = 50 μm, filled arrowheads indicate lipid droplets.) in gonadotrope-ablated (Cre+) and control (Cre−) ovariectomized (OVX) female and gonadectomized (GDX) male mice. Representative μCT images (i), fractional bone volume (j), bone mineral density (k), and trabecular number (l) of trabecular bone from gonadotrope-ablated (Cre+) and control (Cre−) ovariectomized (OVX) female and gonadectomized (GDX) male mice. Error bars represent the standard error of the mean. ** = P < 0.01 and *** = P < 0.001. For statistical details, including individual p-values, see Supplementary Data 1. Source data are provided as a Source Data file.
