Fig. 3: Unordered binding.
a A gene may be regulated by the binding of transcription factors (TFs) to some number n of sites. The most general case is that of unordered binding to distinguishable sites. The TFs might bind in any order, and the rates kon and koff of binding and unbinding may be different for each site and depend on the occupancy state of all the other sites. b The graph of states and transitions for unordered binding of n = 3 copies of a ligand.
