Fig. 5: Examples of low-confidence docked models where there may be ambiguity or heterogeneity in the data.
From: Automatic and accurate ligand structure determination guided by cryo-electron microscopy maps
a The deposited model of a phosphoserine lipid in ATPase (EMDB: 21844, PDB: 6WLW, local resolution: 2.75 Å) and the EMERALD-docked model (b) place the fatty acid tails in strong density, but have differences in the head group. The lowest-energy models for all three triplicates find the same lipid tail orientations (dark blue). c The deposited model of LY3154207 bound to DRD1 (EMDB: 30395, PDB: 7CKZ, local resolution: 3.09 Å) and EMERALD-docked model (d) adopt different conformations. With low-resolution density and few residue binding partners, both models are equally plausible.
