Fig. 6: An integrated model of TREK1 lower pore gating.
From: Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1
Comparison of the POPA and POPE bound TREK1 structures. In the POPA structure (a), the lipid pathway is closed, with no lipid occluding the ion-conducting pore and positively charged residues (blue) in the distal end of TM4 enveloping the anionic POPA headgroup. In the POPE structure (b), hydrophobic residues (green) on TM2, TM3, TM4, and pore helix 2 line the open lipid pathway. c A cartoon schematic describing the proposed integrated model of lower pore gating in TREK1 channels. In the leftmost panel, iso represents the binding site position of the volatile anesthetic isoflurane53.
