Fig. 3: Clonality of the inducible and non-induced reservoirs.

a Pie charts representing the proportions of unique (light grey) and clonally expanded (i.e., ≥2 copies, dark grey) proviruses in the p24+ and p24− populations from the 6 participants. Two-sided Fisher’s exact test (p < 0.0001) of the contribution of clonally expanded proviral sequences to the total number of HIV genomes was performed between the two populations. The numbers of HIV genomes are indicated in each pie chart. b Distributions of clonal expansions from the 6 participants. Proportions of clones according to their size are represented for each cell population, with the total number of clonal expansions indicated in the pie charts. Difference in the contribution of clones with ≥5 copies (exploded from the piecharts) between p24+ and p24− cells was tested with two-sided Fisher’s exact test (p = 0.0073). c Clonally expanded proviruses in the p24+ and p24− populations of the 6 participants. Each expansion is depicted by a different color. Shared clones between the p24+ and p24− populations are exploded from the charts and are depicted in solid colors. Contributions of clonal expansions to each population are indicated in the pie charts. The number of shared clones and their copy numbers are indicated in the middle column.