Fig. 2: Conformational differences between IPTG-LacI and DNA-LacI. | Nature Communications

Fig. 2: Conformational differences between IPTG-LacI and DNA-LacI.

From: Ligand-specific changes in conformational flexibility mediate long-range allostery in the lac repressor

Fig. 2

A Uptake plots for peptides marked in C with data presented as means for n = 2 individual measurements on biologically independent samples, except panel iv, for which n = 3 for IPTG-LacI and n = 5 for DNA-LacI. Error bars are standard deviations. B Comparison of fractional differences. Purple: less exchange in DNA-LacI; teal: less exchange in IPTG-LacI. Right-side labels correspond to the labels in (C, top). C Differential exchange, colored as in (B). Striped and dark gray regions indicate no data. PDB ID: 2P9H (ONPF-bound LacI without the tetramerization helix).

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