Fig. 10: Proposed mechanism whereby lack of UBE3A decreases mechanosensation in AS.
From: Linoleic acid improves PIEZO2 dysfunction in a mouse model of Angelman Syndrome
Loss of Ube3a expression increases cofilin leading to a decrease in actin filaments. Reduced actin filaments decrease PIEZO2 function as well as neuron mechano-excitability. LA increases PIEZO2 function and ameliorates gait deficits. Created with BioRender.com.
