Fig. 6: Phenome-wide association study for kidney genes.
Phenome-wide association study of genes identified in our single variant ExWAS or gene-based study with other phenotypes in the UK Biobank. For every gene, the odds ratio or beta of the UK Biobank phenotype with the smallest p-value of a gene-based association test is displayed. Genes with multiple significant phenotype associations are marked with an asterisk (*). Full results, including numbers of biologically independent samples for all shown UK phenotypes, are available in Supplementary Data 5. Only UK Biobank associations with p-value < 5 × 10−8 (as reported by the respective studies), and more than 5 cases (for binary traits) or more than 5 individuals (for quantitative traits) were considered. a Odd ratios are shown as center points with error bars representing 95% confidence intervals for binary traits. b Betas are shown as center points with error bars representing 95% confidence intervals for quantitative traits, resulting from a linear regression model correcting for age, sex, and age × sex.
