Fig. 4: ICG develops echinocandin-resistant mutations. | Nature Communications

Fig. 4: ICG develops echinocandin-resistant mutations.

From: Macrophage internalization creates a multidrug-tolerant fungal persister reservoir and facilitates the emergence of drug resistance

Fig. 4

a Echinocandin resistance and survival rates of C. glabrata cells incubated in macrophages and RPMI containing micafungin (0.125 µg/ml) were evaluated. At each time-point, C. glabrata cells were collected, a portion was spread on YPD to assess survival and the other portion was plated on YPD plates containing micafungin (0.125 µg/ml) to determine the ECR rate. b The dynamics of killing (top panel) and the numbers of ECR colonies (bottom panel) detected at different time-points are shown for both ICG and planktonic cells cultured in the presence of 0.125 µg/ml micafungin. n = 3 biological replicates over 3 independent experiments. ICG intracellular C. glabrata, ECR echinocandin resistant. Data are presented as mean values +/− standard deviations.

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