Fig. 3: Tonsil vaccination induced significant levels of SIVmac251.6 neutralizing antibodies that inversely correlated with plasma viral loads. | Nature Communications

Fig. 3: Tonsil vaccination induced significant levels of SIVmac251.6 neutralizing antibodies that inversely correlated with plasma viral loads.

From: Direct intranodal tonsil vaccination with modified vaccinia Ankara vaccine protects macaques from highly pathogenic SIVmac251

Fig. 3

SIVmac251 specific (a) gp120 binding antibody (week 0 control vs week 2 control P = ns; week 0 control vs week 0 tonsil MVA P = 0.0011; week 2 control vs week 0 tonsil MVA P = 0.0011; week 2 control vs week 2 tonsil MVA P = 0.0011; week 0 tonsil MVA vs week 2 tonsil MVA P = 0.0011). Data are presented as mean values + /– standard error, Statistical analysis was performed using one-tailed Mann–Whitney U test and a P < 0.05 (*) was considered significant. Error bars represent standard error. (b) SIVmac251 specific neutralizing antibody responses in control (n = 6) and tonsil vaccinated (n = 6) animals at 0 and 2 weeks post infection. (c) SIVmac251.6 specific neutralizing antibody levels in the plasma of control (n = 6) and tonsil vaccinated (n = 6) animals at 0 and 2 weeks post infection (week 0 control vs week 2 control P = ns; week 0 control vs week 0 tonsil MVA P = 0.0076; week 2 control vs week 0 tonsil MVA P = 0.0076; week 2 control vs week 2 tonsil MVA P = 0.0011; week 0 tonsil MVA vs week 2 tonsil MVA P = 0.0011). Data are presented as mean values + /– standard error. Statistical analysis was performed using one-tailed Mann–Whitney U test and a P < 0.05 (*) was considered significant. * indicate P < 0.05. Error bars represent standard error. (d) Correlation between plasma viral loads and anti-SIVmac251.6 neutralizing antibody levels at 2 weeks post infection was determined using Spearman’s rank test and a P < 0.05 was considered significant.

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