Fig. 6: Tonsil vaccination induced high levels of T cell ELISPOT responses prior to challenge. | Nature Communications

Fig. 6: Tonsil vaccination induced high levels of T cell ELISPOT responses prior to challenge.

From: Direct intranodal tonsil vaccination with modified vaccinia Ankara vaccine protects macaques from highly pathogenic SIVmac251

Fig. 6

SIVmac239 (a) env (week 1 control vs week 1 post-MVA P = 0.0006; week 4 control vs week 4 post-MVA P = 0.0006) and (b) gag (week 1 control vs week 1 post-MVA P = 0.0006; week 4 control vs week 4 post-MVA P = 0.0006) specific T cell responses in PBMC by ELISPOT assay at 1 and 4 weeks after tonsil vaccination (n = 7) prior to challenge with SIVmac251 as compared to control (n = 6) animals. Data arereported as spot forming counts (SFC)/106 cells. Box plots show minima, 25% percentile, median, 75 percentile and maxima. Statistical analysis was performed using one-tailed Mann–Whitney U test and a P < 0.05 (*) was considered significant. * indicate P < 0.05. Error bars represent standard error.

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