Fig. 2: Mutations in PfACS10 can cause collateral sensitivity to distinct chemotypes. | Nature Communications

Fig. 2: Mutations in PfACS10 can cause collateral sensitivity to distinct chemotypes.

From: Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation

Fig. 2

Mean EC50 ± SD values for strains containing mutations in PfACS10 selected in the Dd2-Polδ line (A268D, A268V, and F427L) and in 3D7 (M300I), are shown for MMV897615, MMV665924, and MMV019719. Assays were run in triplicate and at least repeated twice. ANOVA with Dunnett post-tests compared mutations in the Dd2-Polδ line, a p < 0.001, b p = 0.005. Two-sided unpaired Student’s t test compared 3D7 and ACS10M300I_C. c p = 0.0003, d p = 0.0000008, e p = 0.0016. Source data are provided as a Source Data file and in Supplementary Data 1.

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