Fig. 3: Obesity in Gpr10P193S/P193S mutant mice.
From: A rare human variant that disrupts GPR10 signalling causes weight gain in mice
a, b Body weight curves of wild-type (+/+; grey squares), heterozygous (+/P193S; purple triangles) and homozygous Gpr10P193S/P193S (pink circles) male (n = 9, 18 and 7 respectively) and female mice (n = 8, 8 and 5 respectively) maintained on 60% high energy diet from 8 weeks. Data are presented as mean± SEM and were analysed with a mixed-effects analysis followed by Sidak’s multiple-comparison post hoc test. c Daily food intake (g) in wild-type (+/+; grey squares), heterozygous (+/P193S; purple triangles) and homozygous Gpr10P193S/P193S (pink circles) male mice aged 8 weeks on normal chow (n = 12, 13 and 13 respectively). d, e Oxygen consumption (VO2, ml/hr) across the light-dark cycle in male wild-type (+/+; grey squares), heterozygous (+/P193S; purple triangles) and homozygous Gpr10P193S/P193S (pink circles) mice on standard chow at 8 weeks (n = 9, 9 and 11 respectively). Data are presented as mean ± SEM and comparisons made using two-way ANOVA followed by Bonferroni’s multiple-comparison post hoc tests. Source data are provided as a Source data file.
