Fig. 7: HP1γ facilities chromatin accessibility of genes governing drug sensitivity.
From: Deacetylation induced nuclear condensation of HP1γ promotes multiple myeloma drug resistance
a ATAC-seq profile of chromatin accessibility of genes in the Vector and HP1γ overexpressing LP-1 cells (n = 3 biologically independent experiments). b Genome-wide distribution of HP1γ accessibility regions in the Vector and HP1γ overexpressing LP-1 cells. c ATAC-seq profile of chromatin accessibility of genes in the WT and BR LP-1 cells (n = 3 biologically independent experiments). d Genome-wide distribution of HP1γ accessibility regions in the WT and BR LP-1 cells. e Gene tracks showing representative ATAC-Seq profiles at FOS, JUN and CD40 gene loci in LP-1 cells stably expressing vector or HP1γ OE, and (f) WT and BR LP-1 cells. g Gene tracks shows representative ATAC-Seq profiles at FOS, JUN and CD40 gene loci in 3 MM patients with disease progression before and after BTZ-based treatment. Source data are provided as a Source data file.
