Fig. 1: Schematic illustration of Smad4 mRNA nano-lantern.

a Synthesis and modification of Smad4 mRNA. b Synthesis of RGD-modified circular staple RNA. c Construction of lantern-shaped flexible origami. d Possible structures of the Smad4 mRNA nano-lantern (5 bs). e Delivery of the mRNA nano-lantern into targeted cells and potential use in studying growth suppression in colorectal cancer. Created with BioRender.com.