Fig. 1: Overall structure and inter-hemichannel docking interface of human Cx36.
From: Cryo-EM structures of human Cx36/GJD2 neuronal gap junction channel
a Cryo-EM reconstruction map and ribbon representation of Cx36LMNG-BRIL. The density and atomic model of Cx36, CHS, acyl chain, and water molecules are colored green, orange, gray, and red, respectively. The ambiguous densities of detergent micelles and BRIL are colored white. The size of each part of the protein (middle), the channel diameter, and the solvent-accessible pore diameter (right) are represented. b Two CHS densities and one acyl chain density covering the surface-exposed NTH-binding site at the channel entrance. c Comparison of the junctional docking regions of Cx36 and Cx26 (PDB code 2ZW3). EC extracellular space, CHS cholesteryl hemisuccinate, ECL extracellular loop, NTH N-terminal helix.
