Fig. 1: Short-term immunization of cynomolgus monkeys with MeV-NP protects against Lassa fever.
From: Rapid protection induced by a single-shot Lassa vaccine in male cynomolgus monkeys
A Outline of the experiment. Scheme presenting the three animal groups with MeV-NP immunizations indicated by blue arrows, LASV challenge by purple arrows, sampling by black arrows, and necropsy by red arrows, with the number of necropsies indicated above the arrows. D-16: animals immunized with MeV-NP 16 days before challenge. D-8: animals immunized with MeV-NP 8 days before challenge. H + 1: animals immunized with MeV-NP 1 h after challenge. CT: unvaccinated control animals. B Evolution of the individual clinical scores in animals over time after the LASV infection. C Monitoring of body temperature by real-time measurement during the course of LASV infection. D Analysis of ALT, AST, and CRP plasma concentrations during the course of LASV infection. For B–D, individual data are presented for each monkey. Source data are provided as a Source Data file.
