Fig. 5: LASV-specific T-cell responses induced after LASV challenge.
From: Rapid protection induced by a single-shot Lassa vaccine in male cynomolgus monkeys
A Quantification of the percentage of CD4+ T cells expressing IFNγ (left panel) or CD154 (right panel) in response to stimulation with LASV-derived GP peptides. B Quantification of the percentage of CD4+ T cells expressing IFNγ (left panel) or CD154 (right panel) in response to stimulation with LASV-derived NP peptides (D-16 vs CT, p = 0.0382). C Quantification of the percentage of CD8+ T cells expressing IFNγ (left panel) or CD137 (right panel) in response to stimulation with LASV-derived GP peptides. D Quantification of the percentage of CD8+ T cells expressing IFNγ (left panel) or CD137 (right panel) in response to stimulation with LASV-derived NP peptides. The percentage of T cells is presented according to the time after challenge after subtraction of the respective value measured for unstimulated T cells. Each bar represents the mean ± SEM of three samples. A Kruskal–Wallis test was used after testing for normality with a Shapiro–Wilk normality test. Statistical significance: *p ≤ 0.05. Source data are provided as a Source Data file.
